Improving HPV vaccine uptake by correcting misinformation on social media

An inoculation theory-based messaging intervention addressing misinformation about HPV vaccine on social media: The Inoculate for HPV Vaccine randomized controlled trial

NIH-funded research University of Pennsylvania · NIH-11078765

This study is looking to help parents of kids aged 8-11 by finding and correcting false information about the HPV vaccine that’s spreading on social media, so they feel more confident in getting their children vaccinated.

Quick facts

Grant typeR37 grant
Study typeNIH-funded research
Funding institutionUniversity of Pennsylvania NIH-funded
Lab location1 site (Philadelphia, United States)
Project IDNIH-11078765 on NIH RePORTER

What this research studies

This research aims to tackle the issue of misinformation about the HPV vaccine that is prevalent on social media, which has been causing vaccine hesitancy among parents. By utilizing natural language processing, the study will identify common misinformation and develop targeted corrective messages based on established communication theories. These messages will be tested in a randomized controlled trial involving parents of adolescents aged 8-11, with the goal of increasing the initiation and completion rates of the HPV vaccine series. Participants will be followed for 12 months to assess the effectiveness of these interventions.

Who could benefit from this research

Good fit: Ideal candidates for this research are parents of children aged 8-11 who are considering the HPV vaccine for their children.

Not a fit: Patients who are already fully vaccinated against HPV or those outside the age range of 8-11 years may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could significantly increase the uptake of the HPV vaccine among adolescents, leading to better cancer prevention outcomes.

How similar studies have performed: Previous research has shown that targeted communication strategies can effectively counter misinformation and improve vaccination rates, suggesting a promising approach in this study.

Where this research is happening

Philadelphia, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.