Improving how well escitalopram works for kids with anxiety
Official title: Improving the Effectiveness and Safety of Escitalopram in Pediatric Anxiety
Funded at University of Cincinnati · NIH-10868603 · Data updated 2026-11-12
This study is looking at how we can make the anxiety medication escitalopram work better and be safer for kids and teens by using their genetic information to personalize their treatment, so they can feel better with fewer side effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | April 19, 2024 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $556,564 |
| NIH project number | 5R01HD099775-06 |
| Project ID | NIH-10868603 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and adolescents aged 0-21 years who are experiencing anxiety disorders.
✕Less likely to help
Patients who do not have anxiety disorders or are outside the age range of 0-21 years may not benefit from this research.
What this research studies
This research focuses on enhancing the effectiveness and safety of escitalopram, a common medication for anxiety, specifically in children and adolescents. It aims to identify genetic factors that predict how well young patients respond to this treatment, which could help tailor medication dosing to individual needs. By conducting blinded, randomized trials, the study seeks to determine if personalized dosing based on genetic information can lead to better outcomes and fewer side effects for young patients suffering from anxiety disorders.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatment options for children and adolescents with anxiety disorders.
How similar studies have gone: While pharmacogenetic approaches have shown success in adult populations, this specific application in pediatric patients is novel and has not been previously tested.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Strawn, Jeffrey Robert — University of Cincinnati
- Study coordinator: Strawn, Jeffrey Robert
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.