Improving how we visualize and study individual proteins in cells
Extending the temporal and spatial capabilities of single-molecule methods
This study is working on improving ways to see individual proteins in living cells, so scientists can better understand how these proteins behave and interact, which could help in studying various health conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10922778 on NIH RePORTER |
What this research studies
This research focuses on enhancing biological optical microscopy techniques to better observe individual proteins within live cells. By developing new methods to introduce specially labeled proteins into cells, researchers aim to overcome current limitations of existing optical probes, which often photobleach quickly and are difficult to use in live environments. The project will utilize advanced techniques like single molecule fluorescence detection and super-resolution microscopy to track proteins over time, providing insights into their behavior and interactions in real-time.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions related to cellular dysfunction or injury, where understanding protein behavior is crucial.
Not a fit: Patients with conditions that do not involve cellular or molecular abnormalities may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in our understanding of cellular processes and disease mechanisms at the molecular level.
How similar studies have performed: Previous research has shown promise in using advanced microscopy techniques to study cellular processes, indicating that this approach has the potential for success.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Chu, Steven — Stanford University
- Study coordinator: Chu, Steven
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.