Improving how we label medicines for better imaging and tracking
Carbon isotope exchange mediated by vanadium complexes
This project aims to create new chemical tools to add special carbon atoms to medicines, helping us see how they work in the body.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project ID | NIH-11144412 on NIH RePORTER |
What this research studies
This project is developing new chemical methods using special vanadium compounds to attach unique carbon atoms, like Carbon-11 or Carbon-14, to different medicines. These labeled medicines can then be tracked inside the body. For example, Carbon-14 helps scientists understand how a drug is absorbed, distributed, metabolized, and excreted. Carbon-11 is crucial for PET scans, which are imaging tests that can show how organs and tissues are functioning. By making it easier to label a wide range of drugs, this work could lead to more effective drug development and better diagnostic tools.
Who could benefit from this research
Good fit: This foundational chemistry research does not directly involve patients, but future clinical applications might benefit patients undergoing drug metabolism studies or PET imaging.
Not a fit: Patients will not directly participate in or receive immediate benefit from this basic chemical methodology development.
Why it matters
Potential benefit: If successful, this work could speed up the development of new drugs and improve diagnostic imaging techniques by making it easier to track medicines in the body.
How similar studies have performed: Carbon isotope exchange is an emerging area, and this work proposes a novel approach using vanadium catalysts, building on preliminary results and theoretical studies.
Where this research is happening
Miami, United States
- Florida International University — Miami, United States (Active)
Researchers
- Principal investigator: Bukhryakov, Konstantin — Florida International University
- Study coordinator: Bukhryakov, Konstantin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.