Improving how tumors respond to proton beam therapy.
Project 3: Enhanced Sensitivity of Tumors to Proton Beam Therapy: Mechanisms and Biomarkers.
['FUNDING_P01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10929968
This study is looking at how proton beam therapy can be better tailored for different types of tumors by figuring out how they respond to this treatment compared to regular radiation, so that doctors can find the best approach for each patient based on their tumor's unique traits.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10929968 on ClinicalTrials.gov |
What this research studies
This research investigates how proton beam therapy (PBT) can be optimized for treating different types of tumors by understanding the biological differences in how tumors respond to this treatment compared to traditional photon radiation. The study aims to identify specific genomic markers that can predict how effective PBT will be for individual patients. By using advanced techniques to analyze DNA damage and repair mechanisms, researchers hope to uncover the unique biological effects of protons on cancer cells. This could lead to more personalized and effective cancer treatments based on a patient's tumor characteristics.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with various types of cancer who are considering proton beam therapy as a treatment option.
Not a fit: Patients with cancers that are not amenable to proton beam therapy or those who are not undergoing treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cancer treatments using proton beam therapy.
How similar studies have performed: Other research has shown promising results in optimizing cancer treatments based on genomic profiling, suggesting that this approach could also be successful.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GROSSHANS, DAVID R — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: GROSSHANS, DAVID R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.