Improving how topical drugs are formulated and absorbed through the skin
Formulation toolbox for topically applied drugs to account for physical parameters, dynamic metamorphosis and influence of excipients
This study is looking at how well skin creams and ointments work by using special computer models to see how different people absorb the medicine through their skin, so we can make sure these products are safe and effective for everyone.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Certara UK Limited NIH-funded |
| Lab location | 1 site (Sheffield, United Kingdom) |
| Project ID | NIH-10908460 on NIH RePORTER |
What this research studies
This research focuses on enhancing the development of topical drug formulations using advanced modeling techniques. By employing physiologically-based pharmacokinetic (PBPK) modeling, the project aims to predict how drugs are absorbed through the skin in various populations. The study will improve the formulation toolbox by integrating dynamic changes in drug compositions and assessing their impact on drug absorption. This approach will help ensure that topical medications are effective and safe for patients by simulating real-life conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who use topical medications for various skin conditions.
Not a fit: Patients who do not use topical medications or have conditions that require systemic treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective topical medications with improved absorption and bioavailability for patients.
How similar studies have performed: Other research has shown promise in using PBPK modeling for drug development, indicating that this approach could lead to significant advancements in topical drug formulation.
Where this research is happening
Sheffield, United Kingdom
- Certara UK Limited — Sheffield, United Kingdom (Active)
Researchers
- Principal investigator: Clarke, James — Certara UK Limited
- Study coordinator: Clarke, James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.