Improving how skin samples are handled for better testing in skin lymphoma
Official title: Optimizing pre-analytic sample handling for high throughput TCR sequencing in cutaneous T cell lymphoma
Funded at Brigham and Women's Hospital · NIH-10977523 · Data updated 2026-11-12
This study is looking at the best ways to handle skin biopsy samples from people with cutaneous T cell lymphoma to make sure the tests for their T cell genes are accurate, helping doctors diagnose and monitor treatment more effectively.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2020 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $41,625 |
| NIH project number | 3U01CA253190-05S1 |
| Project ID | NIH-10977523 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cutaneous T cell lymphoma who are undergoing skin biopsy procedures.
✕Less likely to help
Patients with other types of lymphoma or those not requiring skin biopsies may not benefit from this research.
What this research studies
This research focuses on enhancing the handling of skin biopsy samples from patients with cutaneous T cell lymphoma (CTCL) to ensure accurate and reliable testing of T cell receptor genes. The study aims to identify the best methods for processing and storing these samples, which are crucial for diagnosing and monitoring treatment responses. By testing different preservation techniques and storage conditions, the researchers hope to minimize DNA degradation and improve the quality of test results. Ultimately, this work will support better patient care by refining the diagnostic process and treatment assessments.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and treatment evaluations for patients with cutaneous T cell lymphoma.
How similar studies have gone: Previous research has shown that optimizing sample handling can significantly improve diagnostic accuracy in similar contexts, indicating a promising approach.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Clark, Rachael Ann — Brigham and Women's Hospital
- Study coordinator: Clark, Rachael Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.