Improving how proteins communicate with cells using advanced technology
Evolution and optimization of synthetic <READ/WRITE> function from and into cells using genetic programming
['FUNDING_R01'] · MICHIGAN STATE UNIVERSITY · NIH-10862822
This study is exploring how to use artificial intelligence to create better proteins that can work with your cells, which could lead to new tools for diagnosing and treating health issues, making it easier for doctors to help you in real-time.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MICHIGAN STATE UNIVERSITY (nih funded) |
| Locations | 1 site (EAST LANSING, UNITED STATES) |
| Trial ID | NIH-10862822 on ClinicalTrials.gov |
What this research studies
This research focuses on using artificial intelligence to enhance the design of proteins and peptides that can interact with cells more effectively. By employing a novel machine learning tool called the Protein Optimization Evolving Tool (POET), researchers aim to manipulate amino acid sequences to create bioactive molecules with improved functions. The project involves cycles of protein evolution to refine these molecules, ultimately aiming to develop new diagnostic and therapeutic tools that can communicate with biological systems in real-time. Patients may benefit from advancements in imaging agents and treatments derived from these optimized proteins.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that could benefit from advanced imaging techniques or novel therapeutic approaches involving protein-based treatments.
Not a fit: Patients with conditions unrelated to protein function or those not requiring advanced imaging techniques may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective diagnostic tools and therapies that improve patient outcomes in various diseases.
How similar studies have performed: Other research in the field of synthetic biology and protein engineering has shown promise, indicating that this approach could yield significant advancements.
Where this research is happening
EAST LANSING, UNITED STATES
- MICHIGAN STATE UNIVERSITY — EAST LANSING, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GILAD, ASSAF A — MICHIGAN STATE UNIVERSITY
- Study coordinator: GILAD, ASSAF A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.