Improving how oral drugs are formulated for better absorption
Official title: Enabling oral drug formulations: mechanistic studies and modeling
Funded at University of Connecticut Storrs · NIH-11143265 · Data updated 2026-11-12
This study is working on creating better oral medications that are easier for your body to absorb, so you can get the most benefit from them without relying too much on expensive testing methods, which could help bring effective treatments to you more quickly and affordably.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project start | August 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $402,500 |
| NIH project number | 5R35GM155235-02 |
| Project ID | NIH-11143265 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who may benefit from this research include those with conditions requiring new or improved oral medications that currently face challenges in absorption.
✕Less likely to help
Patients who are not seeking new oral medications or those whose conditions are not addressed by the types of drugs being formulated may not benefit from this research.
What this research studies
This research focuses on developing advanced formulations for oral drugs that can overcome challenges like poor solubility and low permeability. By using mechanistic studies and modeling, the researchers aim to design drug formulations that enhance bioavailability, which is how well a drug is absorbed in the body. The goal is to reduce reliance on costly animal experiments and trial-and-error methods, ultimately streamlining the drug development process. This could lead to more effective medications reaching the market faster and at a lower cost to patients.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective oral medications that are easier and cheaper to produce.
How similar studies have gone: Previous research has shown promise in improving drug formulations through mechanistic studies, indicating that this approach could lead to significant advancements in drug development.
Where this research is happening
-
University of Connecticut Storrs
Storrs-Mansfield, United States Active
Researchers
- Principal investigator: Li, Na — University of Connecticut Storrs
- Study coordinator: Li, Na
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.