Improving how HIV-fighting broadly neutralizing antibodies work in the body
Mechanisms and means to improve HIV bnAb activity in vivo
['FUNDING_R01'] · DARTMOUTH COLLEGE · NIH-11173713
This project aims to strengthen broadly neutralizing antibodies so they better prevent or control HIV infection in people at risk or living with HIV.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DARTMOUTH COLLEGE (nih funded) |
| Locations | 1 site (HANOVER, UNITED STATES) |
| Trial ID | NIH-11173713 on ClinicalTrials.gov |
What this research studies
This project will test two different strategies to make broadly neutralizing HIV antibodies work more effectively inside the body. Researchers will use stringent laboratory and animal models that mimic seeded HIV infection to see whether these changes delay or prevent systemic virus spread. They will compare blood and tissue virus levels over time to measure how well each approach suppresses HIV. The results will be used to guide future efforts to develop antibody-based prevention or treatment options for people.
Who could benefit from this research
Good fit: People who might eventually benefit include individuals at high risk for HIV exposure and people living with HIV who could be candidates for antibody-based prevention or treatment trials.
Not a fit: Patients whose virus is resistant to the specific antibodies tested, or who cannot receive antibody therapies for medical reasons, may not benefit from these approaches.
Why it matters
Potential benefit: If successful, this work could lead to antibody-based products that give stronger or longer protection against HIV and better control of viral levels in people with infection.
How similar studies have performed: Animal studies have shown strong prevention with some broadly neutralizing antibodies, but recent human trials produced mixed results, protecting against only some susceptible strains.
Where this research is happening
HANOVER, UNITED STATES
- DARTMOUTH COLLEGE — HANOVER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ACKERMAN, MARGARET E — DARTMOUTH COLLEGE
- Study coordinator: ACKERMAN, MARGARET E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus