Improving how drugs are delivered to the brain
Official title: A Novel Method to Enhance Drug Delivery to the Brain
Funded at University of Kansas Lawrence · NIH-11078724 · Data updated 2026-11-12
This study is exploring new ways to help medicines get into the brain more easily, which could lead to better treatments for conditions like Alzheimer's disease and other brain disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Lawrence NIH-funded |
| Lab location | 1 site (Lawrence, United States) |
| Project start | May 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $407,243 |
| NIH project number | 5R01AG082273-02 |
| Project ID | NIH-11078724 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from central nervous system disorders, particularly those with conditions like Alzheimer's disease or acquired brain injuries.
✕Less likely to help
Patients with conditions that do not involve the central nervous system or those who are not experiencing issues with drug absorption may not benefit from this research.
What this research studies
This research focuses on overcoming the challenges of delivering therapeutic agents across the blood-brain barrier (BBB), which is crucial for treating various central nervous system disorders. The team has developed novel BBB modulators that can enhance the delivery of drugs, including therapeutic proteins, directly to the brain. By using advanced techniques such as virtual screening and 3D models, the researchers aim to optimize these modulators to improve drug absorption in the brain while minimizing effects on other parts of the body. This approach could lead to more effective treatments for conditions like Alzheimer's disease and other neurodegenerative disorders.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for brain-related conditions by improving drug delivery to the brain.
How similar studies have gone: Previous research has shown promise in using similar approaches to enhance drug delivery across the blood-brain barrier, indicating potential for success in this novel method.
Where this research is happening
-
University of Kansas Lawrence
Lawrence, United States Active
Researchers
- Principal investigator: Siahaan, Teruna J. — University of Kansas Lawrence
- Study coordinator: Siahaan, Teruna J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.