Improving how biological samples are prepared for NMR analysis
Expanding the Scope of NMR Sample Preparation
['FUNDING_OTHER'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11021091
This study is working on improving how we prepare samples of membrane proteins for a special type of analysis called NMR, which helps scientists understand how these proteins work in their natural settings, making the process quicker and easier for researchers.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11021091 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing the preparation of biological samples for solid-state Nuclear Magnetic Resonance (NMR) analysis, which is crucial for understanding the structure and function of membrane proteins. The project aims to develop new tools that streamline the transfer of samples into specialized rotors, making the process faster and more reliable. Additionally, it seeks to create methods for studying membrane proteins in conditions that mimic their natural environments, allowing for better insights into their behavior and characteristics. By addressing these challenges, the research hopes to advance the field of structural biology significantly.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to membrane protein dysfunction, which may include various neurological and metabolic disorders.
Not a fit: Patients with conditions unrelated to membrane proteins or those not requiring NMR analysis for their treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved techniques for studying membrane proteins, which are vital for many biological processes and drug development.
How similar studies have performed: While the approach of enhancing NMR sample preparation is innovative, similar advancements in structural biology have shown promise in improving our understanding of protein functions.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HENZLER-WILDMAN, KATHERINE ANNE — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: HENZLER-WILDMAN, KATHERINE ANNE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.