Improving hormone therapy effectiveness for endometrial cancer
Restoring Progestin Sensitivity in Endometrial Cancer
This study is looking for better ways to help people with endometrial cancer respond to progestin therapy by figuring out why it stops working over time and finding new treatment combinations that could improve results.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11179172 on NIH RePORTER |
What this research studies
This research focuses on enhancing the effectiveness of progestin therapy for patients with endometrial cancer, a condition where current treatments have shown limited success. The study aims to understand the molecular mechanisms that lead to decreased sensitivity to progestins over time, which is crucial for effective treatment. By identifying ways to restore the expression of progesterone receptors in tumor cells, the researchers hope to develop new combinations of treatments that can improve patient outcomes. The approach includes laboratory experiments and mouse models to test the effectiveness of these new strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with endometrial cancer who have experienced a loss of responsiveness to progestin therapy.
Not a fit: Patients with endometrial cancer who have not undergone progestin therapy or those with advanced-stage disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and treatment responses for patients with endometrial cancer.
How similar studies have performed: Previous research has shown promise in enhancing hormone therapy effectiveness in other cancers, suggesting potential for success in this novel approach.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Yang, Shujie — University of Iowa
- Study coordinator: Yang, Shujie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.