Improving HIV treatment by targeting hidden virus reservoirs in macaques
Enhanced latency reversal and reservoir clearance in macaques
This study is exploring new ways to help people with HIV by finding and getting rid of hidden spots in the body where the virus can hide, so it doesn't come back after treatment stops, and it's being tested in macaques to see how well these treatments work.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11086687 on NIH RePORTER |
What this research studies
This research investigates new methods to eliminate hidden reservoirs of HIV in the body, which are responsible for the virus reactivating after treatment stops. The approach involves using a combination of therapies to activate latent HIV and enhance the body's ability to clear infected cells. By studying macaques, researchers aim to understand how these treatments can effectively reduce the virus levels and potentially lead to a cure. The study will utilize advanced techniques to analyze the effects of these treatments on immune cells and viral activity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and have a suppressed viral load.
Not a fit: Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective HIV treatments that may eventually allow patients to stop daily medication without the risk of the virus returning.
How similar studies have performed: Previous research has shown promise in similar approaches targeting latent HIV reservoirs, but this specific method is still being explored.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Chahroudi, Ann M — Emory University
- Study coordinator: Chahroudi, Ann M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.