Improving HIV prevention with pre-exposure prophylaxis
Combining sources of information to improve HIV pre-exposure prophylaxis
This work combines information from past clinical trials to better understand and improve HIV prevention methods like PrEP for people at risk.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11114052 on NIH RePORTER |
What this research studies
We are looking at existing data from large clinical trials, like HPTN 083, iPrEx, and VOICE, to learn more about how well different HIV prevention medications work. By using advanced computer modeling and statistical methods, we can compare new PrEP options, such as long-acting injectable cabotegravir, to older methods without needing new direct trials. This approach helps us understand the effectiveness of these medications for different groups, including men who have sex with men and women, and can guide future prevention strategies.
Who could benefit from this research
Good fit: This work is relevant for individuals at risk of HIV infection who are considering or currently using pre-exposure prophylaxis (PrEP).
Not a fit: Patients not at risk for HIV infection or not considering PrEP would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to more effective and easier-to-use HIV prevention options, helping more people stay healthy.
How similar studies have performed: Combining data from multiple trials using advanced statistical methods is a recognized approach to gain new insights when direct comparisons are not feasible.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Zivich, Paul Nicholas — Univ of North Carolina Chapel Hill
- Study coordinator: Zivich, Paul Nicholas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.