Improving HIV and TB care for pregnant people, infants, children, and teens
IMPAACT Leadership Group
This international network works to find safer, longer‑lasting HIV and TB treatments and ways for pregnant and postpartum people, infants, children, and adolescents to have safe periods without daily HIV medicine.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11457797 on NIH RePORTER |
What this research studies
This program runs clinical studies at sites around the world to test medicines and care approaches for pregnant and postpartum people, infants, children, and adolescents affected by HIV and TB. Researchers study drug dosing, safety, how well medicines suppress the virus, and steps needed for licensing drugs for these age groups. Some projects aim to reduce or pause daily antiretroviral therapy by targeting the virus reservoir or improving immune control after treatment. The network also develops better ways to prevent, diagnose, and treat tuberculosis in people with and without HIV.
Who could benefit from this research
Good fit: Ideal candidates include pregnant or postpartum people living with HIV, infants, children, and adolescents with HIV, and people in these groups who are at risk for or co-infected with TB who receive care at participating sites.
Not a fit: People without HIV, those outside trial age or health eligibility criteria, or those who cannot access an IMPAACT site may not receive direct benefit from participation.
Why it matters
Potential benefit: If successful, this work could lead to safer, simpler HIV and TB treatments, improved health for mothers and children, and new options for controlled periods off daily HIV medicines.
How similar studies have performed: Many antiretroviral and TB treatment approaches have proven effective, while ART‑free remission strategies are promising but remain experimental and less established.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Nachman, Sharon a — Johns Hopkins University
- Study coordinator: Nachman, Sharon a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.