Improving HIV and TB care for pregnant people, babies, children, and teens
IMPAACT Leadership Group
This program tests longer‑lasting HIV and TB treatments and new ways to safely reduce or stop daily HIV medicines for pregnant and postpartum people, infants, children, and adolescents.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11457796 on NIH RePORTER |
What this research studies
You would join a network that runs clinical trials at hospitals and clinics around the world to try new HIV and TB medicines and dosing for pregnant people, babies, children, and teens. Trials include studies of drug levels, safety, how well the virus is controlled, and longer‑acting formulations that might reduce daily pill burdens. The network also tests strategies aimed at ART‑free remission and addresses co‑infections and complications that affect these groups. Findings are used to change dosing, regimens, and approvals so treatments are safer and more practical for patients.
Who could benefit from this research
Good fit: People living with or exposed to HIV — including pregnant and postpartum people, infants, children, and adolescents — and individuals with or at risk for TB who receive care at participating sites are the main candidates.
Not a fit: People without HIV or TB, or those who cannot attend an IMPAACT network clinic or who do not meet specific trial eligibility rules, are unlikely to receive direct benefit from this program.
Why it matters
Potential benefit: Could lead to safer, longer‑lasting HIV and TB treatments, fewer daily medicines for young people and pregnant people, and new approaches toward controlling HIV without continuous therapy.
How similar studies have performed: Prior pediatric and long‑acting ART trials have shown promising results for safety and convenience, while ART‑free remission approaches remain largely experimental.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Nachman, Sharon a — Johns Hopkins University
- Study coordinator: Nachman, Sharon a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.