Improving HIV and cervical cancer prevention in Zimbabwe
Implementing HIV/Cervical Cancer Prevention CASCADE Clinical Trials in Zimbabwe (ZIM-CASCADE)
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11393263
This project brings better cervical cancer screening and same-day treatment options to women living with HIV in Zimbabwe.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11393263 on ClinicalTrials.gov |
What this research studies
If you are a woman living with HIV in Zimbabwe, you may be offered HPV-based screening instead of visual inspection and faster, point-of-care treatment like cryotherapy or thermal ablation. The project works with local clinics and partners to expand screening coverage and make treatment available right after a positive test when possible. It draws on existing care networks that already reach tens of thousands of women to deliver services at the clinic level. The team will track outcomes and service delivery to refine which screening and treatment approaches work best in this setting.
Who could benefit from this research
Good fit: Women living with HIV who receive care at participating clinics in Zimbabwe are the intended participants.
Not a fit: People without HIV, men, those who do not live near or attend participating clinics in Zimbabwe, or women already with advanced invasive cervical cancer may not benefit directly from the screening-focused activities.
Why it matters
Potential benefit: If successful, more women with HIV could be diagnosed earlier and receive prompt treatment, which could lower deaths from cervical cancer.
How similar studies have performed: Similar approaches using HPV testing and same-day treatment have improved detection and treatment in other low-resource settings, though tailoring them for women with HIV is still being refined.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHIRENJE, ZVAVAHERA MIKE — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: CHIRENJE, ZVAVAHERA MIKE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus, Cancer Prevention Intervention, Cancer Prevention Trial, Cancer Treatment