Improving heart rhythm control after open heart surgery without medication.
Non-Pharmacologic Approach to Rhythm Control and Rate Control of Postoperative Atrial Fibrillation.
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-11094794
This study is looking for new ways to help people manage heart rhythm problems after surgery without using medications, by learning more about how inflammation affects the heart, and it’s being tested in dogs to find better treatments for everyone.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11094794 on ClinicalTrials.gov |
What this research studies
This research focuses on finding non-drug methods to manage postoperative atrial fibrillation (POAF), a common complication after heart surgery. It aims to explore alternative strategies for rhythm and rate control, particularly through understanding the underlying mechanisms of POAF using a canine model. By investigating the role of inflammation in the atria, the research seeks to develop more effective treatments that do not rely on traditional medications, which often have limited effectiveness and can cause adverse effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have undergone open heart surgery and are experiencing postoperative atrial fibrillation.
Not a fit: Patients who have not had heart surgery or those with atrial fibrillation due to other causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for patients experiencing atrial fibrillation after heart surgery.
How similar studies have performed: While there have been studies on atrial fibrillation management, this approach focusing on non-pharmacologic strategies in a canine model is relatively novel.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEE, SEUNGYUP — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: LEE, SEUNGYUP
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.