Improving heart rhythm control after open heart surgery without medication.
Official title: Non-Pharmacologic Approach to Rhythm Control and Rate Control of Postoperative Atrial Fibrillation.
Funded at Case Western Reserve University · NIH-11094794 · Data updated 2026-11-12
This study is looking for new ways to help people manage heart rhythm problems after surgery without using medications, by learning more about how inflammation affects the heart, and it’s being tested in dogs to find better treatments for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $402,500 |
| NIH project number | 5R01HL167672-03 |
| Project ID | NIH-11094794 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who have undergone open heart surgery and are experiencing postoperative atrial fibrillation.
✕Less likely to help
Patients who have not had heart surgery or those with atrial fibrillation due to other causes may not benefit from this research.
What this research studies
This research focuses on finding non-drug methods to manage postoperative atrial fibrillation (POAF), a common complication after heart surgery. It aims to explore alternative strategies for rhythm and rate control, particularly through understanding the underlying mechanisms of POAF using a canine model. By investigating the role of inflammation in the atria, the research seeks to develop more effective treatments that do not rely on traditional medications, which often have limited effectiveness and can cause adverse effects.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for patients experiencing atrial fibrillation after heart surgery.
How similar studies have gone: While there have been studies on atrial fibrillation management, this approach focusing on non-pharmacologic strategies in a canine model is relatively novel.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Lee, Seungyup — Case Western Reserve University
- Study coordinator: Lee, Seungyup
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.