Improving heart repair in diabetes by modifying cell behavior
Restoration of myocardial reparative function of diabetic progenitor cells by epigenetic modulation
This study is looking at ways to help special cells from your bone marrow, called endothelial progenitor cells, work better to heal heart tissue in people with diabetes, so they can improve blood vessel growth and repair.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10521253 on NIH RePORTER |
What this research studies
This research investigates how to enhance the ability of specific cells from bone marrow, known as endothelial progenitor cells (EPCs), to repair heart tissue in diabetic patients. The approach focuses on understanding and reversing the dysfunction of these cells caused by diabetes, which impairs their ability to promote blood vessel growth and repair. By using epigenetic modulation, the study aims to restore the reparative functions of these cells, potentially leading to better outcomes for patients with heart issues related to diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are diabetic patients experiencing cardiovascular issues or those at risk of ischemic injuries.
Not a fit: Patients without diabetes or those who do not have cardiovascular complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve heart repair mechanisms in diabetic patients, leading to better management of cardiovascular diseases.
How similar studies have performed: Previous research has shown promise in enhancing cell-based therapies for heart repair, but this specific approach focusing on epigenetic modulation in diabetic patients is relatively novel.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Kishore, Raj — Temple Univ of the Commonwealth
- Study coordinator: Kishore, Raj
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.