Improving heart recovery after cardiac arrest using a special peptide
Peptide-Mediated Enhancement of Akt During Resuscitation and Reperfusion
This study is looking at a new treatment called TAT-PHLPP9c that might help the heart recover better during and after cardiac arrest by improving blood flow to the brain and heart during CPR, and it's being tested in animals to see if it can lead to better survival and brain health for people in this situation.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10912822 on NIH RePORTER |
What this research studies
This research investigates a novel peptide called TAT-PHLPP9c that may enhance heart recovery during and after cardiac arrest. The approach involves administering this peptide during cardiopulmonary resuscitation (CPR) to improve blood flow to the brain and heart, potentially leading to better survival rates and neurological outcomes. The study uses animal models to assess the effectiveness of this treatment, focusing on its ability to activate important metabolic pathways that support heart function. If successful, this could lead to new therapies for patients experiencing cardiac arrest.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced out-of-hospital cardiac arrest and are undergoing resuscitation efforts.
Not a fit: Patients who have not experienced cardiac arrest or those with pre-existing severe neurological deficits may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and neurological outcomes for patients who experience cardiac arrest.
How similar studies have performed: Previous studies have shown promising results with similar approaches in animal models, indicating potential for success in human applications.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Justice, Cody Nicholas — University of Illinois at Chicago
- Study coordinator: Justice, Cody Nicholas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.