Improving heart preservation for transplantation
Prolonged Normothermic Ex vivo Heart Perfusion (NEVHP)
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10889078
This study is looking at a new way to keep donor hearts healthy longer before they are transplanted, which could help more people get the heart they need by making it easier to match donors with recipients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10889078 on ClinicalTrials.gov |
What this research studies
This research investigates a method called prolonged normothermic ex vivo heart perfusion (NEVHP) to enhance the preservation of donor hearts before transplantation. By using advanced techniques such as plasma exchange and continuous hemofiltration in animal models, the study aims to maintain heart function for extended periods, allowing for better matching of donor hearts to recipients. The ultimate goal is to make heart transplantation more elective and increase the availability of viable donor organs.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients awaiting heart transplantation who may benefit from improved donor heart preservation techniques.
Not a fit: Patients who are not candidates for heart transplantation or those with conditions that preclude them from receiving a transplant may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the outcomes of heart transplantation by increasing the number of viable donor hearts and ensuring better matches for patients.
How similar studies have performed: Previous research has shown promising results in heart preservation techniques, indicating that this approach has the potential for success in clinical applications.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROJAS-PENA, ALVARO — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: ROJAS-PENA, ALVARO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.