Improving heart health by treating sleep problems
Official title: Strengthening Hearts by Addressing DisruptEd Sleep (SHADES) Mechanistic Trial
Funded at Indiana University Indianapolis · NIH-11160058 · Data updated 2026-11-12
This study is looking at how trouble sleeping might affect heart health, and it’s for adults with insomnia who will try a special therapy to see if it helps them sleep better and lowers their risk of heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $60,831 |
| NIH project number | 3R01HL165115-02S1 |
| Project ID | NIH-11160058 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who experience insomnia and are at risk for cardiovascular disease.
✕Less likely to help
Patients who do not have insomnia or existing cardiovascular issues may not benefit from this research.
What this research studies
This research investigates the link between insomnia and cardiovascular disease (CVD), aiming to identify how sleep issues can contribute to heart problems. It focuses on understanding the biological mechanisms behind this relationship, such as inflammation and metabolic changes. The study will involve adults with insomnia, who will receive cognitive-behavioral therapy for insomnia (CBT-I) to see if it reduces their risk of developing CVD. By addressing sleep disorders, the research seeks to improve overall heart health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cardiovascular disease by effectively treating insomnia.
How similar studies have gone: Previous research has shown promising results in using cognitive-behavioral therapy for insomnia to reduce inflammation markers associated with cardiovascular disease.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Stewart, Jesse C — Indiana University Indianapolis
- Study coordinator: Stewart, Jesse C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.