Improving heart function through a new approach to cardiac muscle contraction
Official title: Troponin I phosphorylation as a novel novel cardiac inotrope
Funded at Ohio State University · NIH-11052653 · Data updated 2026-11-12
This study is looking at a new way to help people with heart disease by focusing on a protein called troponin I, aiming to improve heart function without the side effects that come from traditional treatments, and it could lead to safer options for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $567,962 |
| NIH project number | 5R01HL164795-03 |
| Project ID | NIH-11052653 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with heart disease who experience insufficient heart function.
✕Less likely to help
Patients with non-cardiac related conditions or those whose heart function is not compromised may not benefit from this research.
What this research studies
This research investigates a novel method to enhance heart function in patients with heart disease by focusing on the protein troponin I. Unlike traditional treatments that increase calcium levels and can lead to harmful side effects, this approach aims to phosphorylate troponin I to improve heart contractions without raising calcium levels. The study will explore how this phosphorylation can enhance cardiac function in both healthy and diseased hearts, using mouse models and human cardiac tissue. The goal is to develop a safer therapeutic option for patients suffering from heart conditions.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment that improves heart function without the adverse effects associated with current therapies.
How similar studies have gone: Previous research has shown promise in targeting troponin I for cardiac function improvement, suggesting potential for success in this novel approach.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Biesiadecki, Brandon J — Ohio State University
- Study coordinator: Biesiadecki, Brandon J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.