Improving heart function in patients with heart failure using a new pacing technique
His-Bundle Corrective Pacing in Heart Failure
This study is looking at a new heart treatment called His-Bundle Corrective Pacing to see if it can help people with heart failure and a specific heart rhythm problem called right bundle branch block, and it will compare this new method to the usual treatment to find out which one works better over six months.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10857312 on NIH RePORTER |
What this research studies
This research investigates a new approach called His-Bundle Corrective Pacing, which aims to improve heart function in patients suffering from heart failure, particularly those with a specific heart rhythm issue known as right bundle branch block (RBBB). The study will compare the effectiveness of this new pacing technique against the traditional method called Biventricular Cardiac Resynchronization Therapy (BIV-CRT). By enrolling 120 patients, the researchers will assess how well His-Bundle Corrective Pacing can enhance heart performance over a six-month period. This trial seeks to provide insights into the mechanisms behind the benefits of this innovative therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with heart failure who have severely reduced left ventricular function and exhibit RBBB on their ECG.
Not a fit: Patients without heart failure or those whose ECG does not show RBBB may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved heart function and reduced hospitalizations for patients with heart failure and RBBB.
How similar studies have performed: While traditional BIV-CRT has been widely studied, His-Bundle Corrective Pacing is an emerging technique that has not yet been extensively tested, making this research novel.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Valentina Kutyifa, Valentina Kutyifa Valentina Kutyifa — University of Rochester
- Study coordinator: Valentina Kutyifa, Valentina Kutyifa Valentina Kutyifa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.