Improving heart function by targeting specific proteins in blood vessels
Official title: Targeting Endothelial Epsins to Ameliorate Myocardial Ischemia
Funded at Boston Children's Hospital · NIH-10944711 · Data updated 2026-11-12
This study is looking at how specific proteins can help improve blood flow and heart function for people with narrowed arteries, aiming to find new ways to support heart healing and recovery after heart attacks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 8, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $833,681 |
| NIH project number | 1R01HL174928-01 |
| Project ID | NIH-10944711 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 years old who have experienced acute myocardial infarction or have significant coronary artery disease.
✕Less likely to help
Patients with non-cardiovascular conditions or those who have not experienced any heart-related issues may not benefit from this research.
What this research studies
This research investigates how certain proteins, known as endothelial epsins, can help improve blood flow and heart function in patients suffering from reduced blood supply due to narrowed arteries. The study aims to understand the molecular mechanisms that govern heart regeneration and repair after events like myocardial infarction. By exploring these mechanisms, the research seeks to identify new ways to stimulate the growth of blood vessels and enhance recovery in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart recovery and reduce the risk of heart failure after a heart attack.
How similar studies have gone: Previous research has shown promise in targeting molecular mechanisms for heart repair, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Chen, Hong — Boston Children's Hospital
- Study coordinator: Chen, Hong
Related research
Other NIH-funded projects on the same topics.
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Targeting endothelial epsins to help the heart heal after a heart attack
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This study is looking at how a small protein called ubiquitin might help the heart heal better after it's been damaged from not getting enough blood, like during a heart attack, by reducing inflammation and scarring.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.