Improving heart function by targeting specific proteins in blood vessels
Targeting Endothelial Epsins to Ameliorate Myocardial Ischemia
['FUNDING_R01'] · BOSTON CHILDREN'S HOSPITAL · NIH-10944711
This study is looking at how specific proteins can help improve blood flow and heart function for people with narrowed arteries, aiming to find new ways to support heart healing and recovery after heart attacks.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10944711 on ClinicalTrials.gov |
What this research studies
This research investigates how certain proteins, known as endothelial epsins, can help improve blood flow and heart function in patients suffering from reduced blood supply due to narrowed arteries. The study aims to understand the molecular mechanisms that govern heart regeneration and repair after events like myocardial infarction. By exploring these mechanisms, the research seeks to identify new ways to stimulate the growth of blood vessels and enhance recovery in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults over 21 years old who have experienced acute myocardial infarction or have significant coronary artery disease.
Not a fit: Patients with non-cardiovascular conditions or those who have not experienced any heart-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart recovery and reduce the risk of heart failure after a heart attack.
How similar studies have performed: Previous research has shown promise in targeting molecular mechanisms for heart repair, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, HONG — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: CHEN, HONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.