Improving heart function by restoring energy production in heart failure.
Official title: Metabolic Resuscitation in Heart Failure.
Funded at Texas A&m University Health Science Ctr · NIH-11000149 · Data updated 2026-11-12
This study is looking at how problems with energy production in the body can affect heart failure, and it aims to find new ways to help the heart work better, which could lead to better treatments for people living with heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $748,829 |
| NIH project number | 1R01HL176015-01 |
| Project ID | NIH-11000149 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with heart failure who may benefit from innovative therapeutic strategies.
✕Less likely to help
Patients with heart failure who have already exhausted all treatment options or have advanced-stage heart failure may not benefit from this research.
What this research studies
This research investigates how a compromised metabolic system affects heart failure and aims to restore energy production in the heart. By exploring a novel metabolic resuscitation mechanism that is downregulated in heart failure patients, the study seeks to understand its role in heart function. Using advanced experimental approaches and genetic animal models, the researchers will identify new therapeutic strategies and potential biomarkers for heart failure treatment. The goal is to provide insights that could lead to improved outcomes for patients suffering from heart failure.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve heart function and quality of life for heart failure patients.
How similar studies have gone: Previous research has shown promise in similar approaches to restoring energy production in heart failure, indicating potential for success in this novel investigation.
Where this research is happening
-
Texas A&m University Health Science Ctr
College Station, United States Active
Researchers
- Principal investigator: Chang, Jiang — Texas A&m University Health Science Ctr
- Study coordinator: Chang, Jiang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.