Improving Heart Failure Care by Targeting the Secretin Receptor
Activation of the Secretin Receptor as a Strategy for the Treatment of Heart Failure
This research explores a new way to help people with heart failure, especially those also affected by obesity and type 2 diabetes, by focusing on a natural body signal called secretin.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project ID | NIH-10983338 on NIH RePORTER |
What this research studies
Heart failure is a serious condition, and while current medications help, many patients still face hospitalizations and a shorter life. We are looking for better ways to improve heart function and reduce side effects compared to existing drug combinations. This involves understanding how a natural hormone called secretin affects the heart and other body functions like appetite and blood sugar. Our goal is to find new medicines that can activate the secretin receptor, potentially offering a more targeted and effective approach to managing heart failure.
Who could benefit from this research
Good fit: This research is relevant for patients living with heart failure, particularly those whose condition is linked to obesity and type 2 diabetes.
Not a fit: Patients without heart failure or those whose condition is not related to the pathways being explored may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new medications for heart failure that are more effective and have fewer side effects than current treatments.
How similar studies have performed: While existing drugs for heart failure have shown success, this specific approach of targeting the secretin receptor with small molecules is a novel area of exploration.
Where this research is happening
Scottsdale, United States
- Mayo Clinic Arizona — Scottsdale, United States (Active)
Researchers
- Principal investigator: Miller, Laurence J — Mayo Clinic Arizona
- Study coordinator: Miller, Laurence J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.