Improving heart cell production from stem cells using genetic tracking.
Official title: Elucidation and improved control of human induced pluripotent stem cell cardiac differentiation by using single-guide RNA-based cellular barcoding to track and manipulate lineages
Funded at University of Texas at Austin · NIH-10934333 · Data updated 2026-11-12
This study is working on improving how we create heart muscle cells from special stem cells, which could help make better treatments for heart disease and personalized care for patients like you.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project start | September 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $40,517 |
| NIH project number | 5F31HL170717-02 |
| Project ID | NIH-10934333 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cardiovascular diseases or conditions that could benefit from improved cardiac cell therapies.
✕Less likely to help
Patients with non-cardiovascular conditions or those who are not eligible for stem cell therapies may not receive any benefit from this research.
What this research studies
This research focuses on enhancing the production of heart muscle cells from human induced pluripotent stem cells (hiPSCs). By utilizing a technique called cellular barcoding, researchers aim to track and manipulate the different lineages of stem cells to understand and improve their differentiation into cardiac cells. This approach addresses the current challenges of variability and inefficiency in producing consistent heart cells, which are crucial for developing better models for heart disease. Patients may benefit from advancements in heart disease treatments and personalized medicine as a result of this research.
Why it matters
Potential benefit: If successful, this research could lead to more reliable and effective treatments for heart diseases by improving the production of heart cells for research and therapeutic purposes.
How similar studies have gone: Previous research has shown promise in using similar genetic tracking techniques to improve cell differentiation, indicating potential success for this approach.
Where this research is happening
-
University of Texas at Austin
Austin, United States Active
Researchers
- Principal investigator: Sohn, Sogu — University of Texas at Austin
- Study coordinator: Sohn, Sogu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.