Improving heart cell function using engineered genes
Engineered BacNav and BacCav for Improved Excitability and Contraction
This study is looking at a new way to help heart cells work better, which could help prevent serious problems like sudden cardiac death and heart failure, by using special genes to boost their performance.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11035092 on NIH RePORTER |
What this research studies
This research focuses on enhancing the excitability and contraction of heart cells to prevent sudden cardiac death and heart failure. It explores the use of engineered genes delivered via adeno-associated viral vectors to improve the function of cardiomyocytes, the cells responsible for heart contractions. By developing smaller versions of sodium and calcium channel genes, the study aims to effectively deliver these genes to heart cells, potentially leading to better heart health outcomes. The research includes preliminary results showing improved heart cell function in laboratory models, indicating a promising approach for treating heart diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have heart conditions that affect cell excitability and contractility.
Not a fit: Patients with non-cardiac conditions or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new gene therapies that significantly improve heart function and reduce the risk of serious cardiac events.
How similar studies have performed: Other research has shown promise in using gene therapy for heart conditions, making this approach a potentially viable option.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Bursac, Nenad — Duke University
- Study coordinator: Bursac, Nenad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.