Improving Heart Attack Recovery with an Injectable Material
Infusible Extracellular Matrix for Treating Myocardial Infarction
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11088290
This project aims to develop a new injectable material to help the heart heal and recover after a heart attack.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11088290 on ClinicalTrials.gov |
What this research studies
Heart failure after a heart attack is a serious concern, and existing cell therapies have shown limited success. This project explores a new approach using an injectable material, called a myocardial matrix hydrogel, which comes from decellularized heart tissue. This material is designed to be delivered minimally invasively, like through a catheter, and then forms a scaffold in the heart. It works by encouraging the body's own immune and other cells to come in and help repair the damaged heart tissue, aiming for better recovery.
Who could benefit from this research
Good fit: Patients who have experienced a heart attack, particularly those in the subacute or chronic phases, might be ideal candidates for future applications of this therapy.
Not a fit: Patients in the immediate aftermath of an acute heart attack may not be suitable for this specific approach due to safety considerations.
Why it matters
Potential benefit: If successful, this new therapy could offer a more effective and less complicated way to help hearts heal after a heart attack, potentially reducing the risk of heart failure.
How similar studies have performed: The initial work with this material has already led to a successful Phase I clinical trial in post-MI patients, indicating promising early results.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHRISTMAN, KAREN L — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: CHRISTMAN, KAREN L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.