Improving healing in severe muscle injuries
Engineering the Immune and Fibrotic Response in Volumetric Muscle Loss
['FUNDING_R01'] · UNIVERSITY OF OREGON · NIH-10892181
This study is looking at ways to help people who have lost a lot of muscle from injuries heal better by understanding what happens in their muscles and finding new treatments to improve recovery.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF OREGON (nih funded) |
| Locations | 1 site (EUGENE, UNITED STATES) |
| Trial ID | NIH-10892181 on ClinicalTrials.gov |
What this research studies
This research investigates how to enhance the healing process in patients with significant muscle loss due to trauma, particularly focusing on the mechanisms that lead to poor recovery outcomes. The team aims to understand the cellular responses in the affected muscle tissue and how certain cells contribute to fibrosis and fat infiltration, which hinder regeneration. By exploring these biological processes, the researchers hope to develop better treatment strategies that could lead to improved muscle repair and function for patients suffering from volumetric muscle loss.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced significant muscle loss due to trauma, particularly those in military or general populations.
Not a fit: Patients with minor muscle injuries or those who do not have volumetric muscle loss may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with severe muscle injuries, improving their recovery and quality of life.
How similar studies have performed: While the approach is based on established principles of muscle regeneration, the specific focus on volumetric muscle loss and the cellular mechanisms involved is relatively novel and has not been extensively tested.
Where this research is happening
EUGENE, UNITED STATES
- UNIVERSITY OF OREGON — EUGENE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WILLETT, NICK J — UNIVERSITY OF OREGON
- Study coordinator: WILLETT, NICK J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.