Improving healing for complex limb injuries
Official title: Regenerative engineering for complex extremity trauma
Funded at Oregon Health & Science University · NIH-11243754 · Data updated 2026-11-12
This study is exploring new ways to help people with serious limb injuries heal better by using special materials and exercise to support the recovery of both muscle and bone, which could mean fewer surgeries and a quicker return to normal activities.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $91,242 |
| NIH project number | 3R01AR080150-03S1 |
| Project ID | NIH-11243754 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from complex lower extremity trauma involving both muscle and bone injuries.
✕Less likely to help
Patients with isolated injuries to either muscle or bone, without the other being affected, may not benefit from this research.
What this research studies
This research focuses on developing new regenerative therapies for patients with severe limb injuries that involve both muscle and bone damage. The approach combines advanced materials that mimic natural tissue structures with exercise to enhance healing. By using nanoscale patterns to guide cell behavior, the research aims to improve the recovery of both muscle and bone, potentially reducing the need for multiple surgeries and long-term rehabilitation. Patients may benefit from a more effective treatment that addresses the complexities of their injuries.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for severe limb injuries, improving recovery times and outcomes for patients.
How similar studies have gone: Previous research has shown promising results using similar regenerative approaches, indicating potential for success in this area.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Nakayama, Karina — Oregon Health & Science University
- Study coordinator: Nakayama, Karina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.