Improving gut health in patients with a genetic disorder affecting sugar processing
Official title: Improving intestinal symptoms in a Congenital Disorder of Glycosylation
Funded at Ut Southwestern Medical Center · NIH-10881362 · Data updated 2026-11-12
This study is looking at a specific genetic condition called MPI deficiency, which affects how your body processes sugars and can cause serious gut problems like diarrhea; researchers are using a special mouse model to learn more about these issues and find new ways to help improve gut health for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $601,661 |
| NIH project number | 1R01DK135511-01A1 |
| Project ID | NIH-10881362 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with congenital disorders of glycosylation, particularly those with MPI deficiency.
✕Less likely to help
Patients without congenital disorders of glycosylation or those not experiencing significant intestinal symptoms may not benefit from this research.
What this research studies
This research focuses on congenital disorders of glycosylation, specifically targeting patients with mannose phosphate isomerase (MPI) deficiency. The study uses a novel mouse model to explore how defects in glycosylation lead to severe intestinal issues, including diarrhea and protein loss. By investigating the role of MPI in the intestines, the researchers aim to identify new therapeutic strategies to enhance gut health and improve patient outcomes. The approach includes examining the importance of glycosylation in mucus production and intestinal barrier function.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from severe intestinal symptoms related to MPI deficiency.
How similar studies have gone: Previous research has shown promise in understanding glycosylation disorders, but this specific approach using a novel mouse model is relatively novel.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Sorelle, Jeffrey — Ut Southwestern Medical Center
- Study coordinator: Sorelle, Jeffrey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.