Improving growth hormone levels in veterans with brain injuries
Official title: Alleviation of chronic TBI through modulation of calcium signaling
Funded at U.s. Dept/vets Affairs Medical Center · NIH-10932861 · Data updated 2026-11-12
This study is looking at how brain injuries from military service can affect hormone levels in veterans, especially those who served in Iraq and Afghanistan, and aims to find new ways to help improve their hormone balance and overall quality of life.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | U.s. Dept/vets Affairs Medical Center NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | October 1, 2023 |
| Project end | September 30, 2025 |
| Funding year | 2025 |
| NIH project number | 5I21RX004379-02 |
| Project ID | NIH-10932861 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans who have experienced chronic traumatic brain injury and are diagnosed with growth hormone deficiency.
✕Less likely to help
Patients who do not have a history of traumatic brain injury or those without growth hormone deficiency may not benefit from this research.
What this research studies
This research investigates how chronic traumatic brain injury (TBI) affects growth hormone levels in veterans, particularly those from Iraq and Afghanistan. It focuses on understanding the dysfunction of the hypothalamic-pituitary axis that leads to growth hormone deficiency (GHD) and its impact on quality of life. The study aims to restore hormone secretion by targeting specific calcium signaling pathways in the anterior pituitary cells, which may enhance axonal regeneration in damaged neurons. By identifying the role of calcium channels in hormone release, the research seeks to develop new therapeutic approaches for managing GHD in these patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for growth hormone deficiency, enhancing the quality of life for veterans suffering from chronic TBI.
How similar studies have gone: Previous research has shown promise in targeting calcium signaling pathways for hormonal regulation, suggesting potential success for this novel approach.
Where this research is happening
-
U.s. Dept/vets Affairs Medical Center
Washington, United States Active
Researchers
- Principal investigator: Bandyopadhyay, Bidhan Chandra — U.s. Dept/vets Affairs Medical Center
- Study coordinator: Bandyopadhyay, Bidhan Chandra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.