Improving glioma diagnosis using blood tests
Standardized Molecular Analyses of Glioma EVs
This study is working on a simple blood test to help doctors find brain tumors called gliomas without needing to do risky surgeries, making it easier and safer for patients to get the information they need about their condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10893518 on NIH RePORTER |
What this research studies
This research focuses on developing a non-invasive blood test to diagnose malignant glioma tumors by analyzing extracellular vesicles (EVs) released by cancer cells. Currently, gliomas are diagnosed through risky brain tissue biopsies, but this project aims to optimize liquid biopsy techniques that can provide real-time monitoring of the tumor's molecular characteristics. The team will evaluate various methods for isolating and characterizing EVs to identify the most effective approach for validating biomarkers associated with gliomas. By utilizing advanced technologies, the goal is to create a reliable blood-based assay that can be used in clinical settings, reducing the need for invasive procedures.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with malignant glioma or those suspected of having this type of brain tumor.
Not a fit: Patients with non-malignant brain tumors or other unrelated conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more accurate diagnosis and monitoring of glioma tumors through a simple blood test.
How similar studies have performed: Previous research has shown promise in using extracellular vesicles for cancer diagnostics, indicating potential success for this innovative approach.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Carter, Bob S — Massachusetts General Hospital
- Study coordinator: Carter, Bob S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.