Improving glioblastoma treatment with radiation therapy
Official title: Utilizing Radiation-Induced Multi-potency to Increase the Efficacy of Radiotherapy
Funded at University of California Los Angeles · NIH-10844584 · Data updated 2026-11-12
This study is looking at ways to make radiation therapy work better for people with glioblastoma, a tough type of brain cancer, by finding new compounds that can help stop cancer cells from becoming resistant to treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $484,078 |
| NIH project number | 5R01CA281682-02 |
| Project ID | NIH-10844584 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with glioblastoma who are undergoing radiation therapy.
✕Less likely to help
Patients with other types of brain tumors or those who are not receiving radiation therapy may not benefit from this research.
What this research studies
This research investigates how radiation therapy can be enhanced to better treat glioblastoma, a type of brain cancer. The approach focuses on understanding how radiation can induce a multipotent state in cancer cells, which may lead to more effective treatment strategies. By developing new compounds that can cross the blood-brain barrier, the research aims to prevent the formation of treatment-resistant cancer stem cells that contribute to tumor regrowth. The methodology includes both laboratory studies and animal models to evaluate the effectiveness of these new compounds in improving patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma, potentially increasing survival rates and improving quality of life for patients.
How similar studies have gone: Previous research has shown promise in targeting cancer stem cells and enhancing radiation therapy, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Pajonk, Frank — University of California Los Angeles
- Study coordinator: Pajonk, Frank
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.