Improving genomic testing in patient care across Indiana
Official title: Implementing a genomics-enabled Learning Health System across Indiana
Funded at Indiana University Indianapolis · NIH-10980962 · Data updated 2026-11-12
This study is looking to improve how doctors use genetic testing to make better treatment decisions for cancer patients and those at risk of kidney disease, so they can receive more personalized care that fits their needs.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | September 23, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $658,448 |
| NIH project number | 1U01HG013770-01 |
| Project ID | NIH-10980962 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include patients receiving fluoropyrimidine chemotherapy or those of African ancestry at risk for chronic kidney disease.
✕Less likely to help
Patients who do not receive fluoropyrimidine chemotherapy or do not have risk factors associated with APOL1 variants may not benefit from this research.
What this research studies
This research aims to enhance how genomic testing is integrated into patient care by developing strategies for effective implementation and use of genetic information in clinical settings. The project will utilize a genomics-enabled learning health system to conduct two clinical trials focused on DPYD testing for patients receiving certain cancer treatments and APOL1 testing for those at risk of chronic kidney disease. By evaluating the impact of these interventions, the research seeks to improve patient outcomes through better-informed treatment decisions and personalized care. The findings will also help share tools and resources that can be adopted by healthcare providers more broadly.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective cancer treatments and improved management of chronic kidney disease for patients.
How similar studies have gone: Previous research has shown success in implementing genomic testing in clinical practice, indicating that this approach has potential for positive outcomes.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Skaar, Todd C. — Indiana University Indianapolis
- Study coordinator: Skaar, Todd C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.