Improving genetic testing for families at risk of Lynch syndrome

Let's Talk: Overcoming barriers to the uptake of cascade screening through a stakeholder-informed online intervention

NIH-funded research Univ of North Carolina Chapel Hill · NIH-10808230

This study is creating an easy-to-use online tool called 'Let's Talk' to help families with Lynch syndrome get the support and information they need for cancer screening, making it simpler for them to communicate and plan for genetic testing.

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionUniv of North Carolina Chapel Hill NIH-funded
Lab location1 site (Chapel Hill, United States)
Project IDNIH-10808230 on NIH RePORTER

What this research studies

This research focuses on enhancing cascade screening for Lynch syndrome, a genetic condition that increases cancer risk among family members. It aims to develop an interactive online intervention called 'Let's Talk' that addresses barriers to screening by providing tailored information and support for patients and their families. The approach involves engaging stakeholders to create a user-friendly platform that facilitates communication and planning for genetic testing. By adapting a previously successful paper-based intervention into an online format, the project seeks to improve accessibility and ongoing support for families affected by Lynch syndrome.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals with Lynch syndrome and their first-degree relatives who may benefit from cascade screening.

Not a fit: Patients who do not have a family history of Lynch syndrome or those who are not first-degree relatives may not receive any benefit from this research.

Why it matters

Potential benefit: If successful, this research could significantly increase the number of family members screened for Lynch syndrome, leading to earlier cancer detection and prevention.

How similar studies have performed: Previous research has shown success with similar interventions in promoting genetic testing and screening, indicating a promising approach for this project.

Where this research is happening

Chapel Hill, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.