Improving genetic risk prediction for complex diseases like cardiovascular issues
Official title: Methods for Enhancing Polygenic Risk Prediction Models for Complex Disease
Funded at University of Pennsylvania · NIH-11085221 · Data updated 2026-11-12
This study is working on improving how we predict the risk of heart diseases by combining genetic information with other important factors, so that patients can get better screening and prevention options tailored to their needs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $769,981 |
| NIH project number | 5R01HL169458-03 |
| Project ID | NIH-11085221 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of cardiovascular diseases or those identified as being at higher genetic risk.
✕Less likely to help
Patients with no genetic predisposition or those without relevant clinical or environmental risk factors may not benefit from this research.
What this research studies
This research focuses on enhancing polygenic risk scores (PRS) to better predict the risk of complex diseases, particularly cardiovascular diseases. By integrating genetic data with clinical, environmental, and social factors, the study aims to create more accurate risk prediction models. This approach addresses the limitations of current PRS models, which often overlook rare genetic variants and other important risk factors. Patients may benefit from improved screening and prevention strategies based on these enhanced models.
Why it matters
Potential benefit: If successful, this research could lead to more accurate risk assessments and targeted prevention strategies for patients at risk of cardiovascular diseases.
How similar studies have gone: Previous research has shown promise in integrating genetic and non-genetic factors for disease risk prediction, suggesting that this approach could yield significant advancements.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Ritchie, Marylyn D — University of Pennsylvania
- Study coordinator: Ritchie, Marylyn D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.