Improving genetic risk assessments for diverse populations.
Official title: BridgePRS: bridging the gap in polygenic risk scores between ancestries.
Funded at Icahn School of Medicine at Mount Sinai · NIH-10930175 · Data updated 2026-11-12
This study is working on improving genetic risk scores to help predict the chances of developing complex diseases for people from different backgrounds, so that everyone can get better, personalized healthcare based on their unique genetics.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 15, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $641,630 |
| NIH project number | 5R01HG012773-02 |
| Project ID | NIH-10930175 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals from diverse and mixed ancestry populations who are interested in understanding their genetic risk for complex diseases.
✕Less likely to help
Patients with a homogeneous genetic background may not benefit significantly from this research.
What this research studies
This research focuses on enhancing polygenic risk scores (PRS) to better estimate genetic risks for complex diseases in diverse and mixed ancestry populations. By utilizing advanced Bayesian hierarchical modeling, the project aims to identify and address the limitations of current PRS methods, which often fail to accurately reflect genetic risks across different ethnic groups. The goal is to create tailored PRS tools that can provide more accurate predictions for individuals from various backgrounds, ultimately improving personalized medicine approaches. This research will involve analyzing genetic data to uncover shared and ancestry-specific risk factors.
Why it matters
Potential benefit: If successful, this research could lead to more accurate genetic risk assessments, enabling better prevention and treatment strategies for individuals from diverse backgrounds.
How similar studies have gone: Previous research has shown promise in improving genetic risk assessments through advanced modeling techniques, indicating that this approach could yield significant advancements.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: O'reilly, Paul Francis — Icahn School of Medicine at Mount Sinai
- Study coordinator: O'reilly, Paul Francis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.