Improving genetic risk assessment for coronary artery disease
Official title: Advancing the clinical actionability of polygenic scores for coronary artery disease
Funded at Massachusetts General Hospital · NIH-10999466 · Data updated 2026-11-12
This study is working to improve how we predict the risk of heart disease by using genetic information from different backgrounds, so we can help identify people at higher risk earlier and offer them better prevention options.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 11, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $170,323 |
| NIH project number | 5K08HL168238-02 |
| Project ID | NIH-10999466 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals from diverse ancestry backgrounds who may be at risk for coronary artery disease.
✕Less likely to help
Patients with established coronary artery disease or those who do not have a genetic predisposition to CAD may not benefit from this research.
What this research studies
This research aims to enhance the accuracy of predicting coronary artery disease (CAD) risk by developing polygenic scores (PGS) that account for genetic variations across diverse populations. The approach involves analyzing multi-ancestry genomic data to create more reliable risk prediction models that integrate both genetic and non-genetic factors. By refining these scores, the research seeks to identify individuals at high risk for CAD earlier in life, allowing for timely preventive measures. The study will also explore new clinical applications for these scores using data from clinical trials.
Why it matters
Potential benefit: If successful, this research could lead to more effective early interventions for individuals at risk of coronary artery disease, potentially reducing mortality rates.
How similar studies have gone: Previous research has shown promise in using polygenic scores for other conditions, indicating potential success for this novel approach in coronary artery disease.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Patel, Aniruddh — Massachusetts General Hospital
- Study coordinator: Patel, Aniruddh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.