Improving genetic predictions for Alzheimer's and other conditions across different populations
Mendelian imputation for family-based GWAS and association-by-proxy in diverse ancestries
This project aims to make genetic predictions for conditions like Alzheimer's more accurate and useful for people from various backgrounds.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11112507 on NIH RePORTER |
What this research studies
We are working to improve how we use genetic information from families to understand diseases like Alzheimer's. Our goal is to develop better tools that can predict health risks more accurately for people of all ancestries. This involves looking at existing genetic data from many families and also including information from individuals without close relatives to make our predictions stronger. Ultimately, we hope to create more reliable genetic risk scores that work well for everyone, regardless of their family background or ethnicity.
Who could benefit from this research
Good fit: This research primarily uses existing genetic data from large groups of people, so direct patient participation is not currently part of this specific grant.
Not a fit: Patients not interested in genetic risk prediction or those whose conditions are not primarily genetically influenced may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to more precise genetic risk assessments for conditions like Alzheimer's disease, helping individuals and their doctors make more informed health decisions.
How similar studies have performed: While genetic studies are common, this project focuses on novel methods to enhance family-based genetic analysis and improve predictions across diverse ancestries, building upon existing GWAS approaches.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Young, Alexander Thomas Ian Strudwick — University of California Los Angeles
- Study coordinator: Young, Alexander Thomas Ian Strudwick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.