Improving genetic diagnosis for male infertility
Official title: Project I
Funded at Magee-Women's Res Inst and Foundation · NIH-10992991 · Data updated 2026-11-12
This study is looking to help men who are having trouble with infertility by using advanced genetic testing to find more hidden causes, which could lead to better diagnoses and treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Magee-Women's Res Inst and Foundation NIH-funded |
| Lab location | 1 site (Pittsburgh, UNITED STATES) |
| Project start | September 1, 2019 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $710,390 |
| NIH project number | 2P50HD096723-06 |
| Project ID | NIH-10992991 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men over 21 years old who are experiencing unexplained infertility.
✕Less likely to help
Patients who do not have male infertility or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on enhancing the understanding and diagnosis of genetic causes of male infertility. By transitioning from whole-exome sequencing to whole genome sequencing, the project aims to identify more genetic variants that contribute to infertility. The researchers will analyze a large database of genetic data to uncover previously overlooked genetic factors and improve diagnostic accuracy. This approach could lead to better clinical outcomes for men struggling with infertility.
Why it matters
Potential benefit: If successful, this research could provide more accurate diagnoses for men with infertility, leading to targeted treatments and improved chances of conception.
How similar studies have gone: Other research has shown success in identifying genetic causes of infertility using similar genomic approaches, indicating a promising avenue for this project.
Where this research is happening
-
Magee-Women's Res Inst and Foundation
Pittsburgh, United States Active
Researchers
- Principal investigator: Conrad, Donald F. — Magee-Women's Res Inst and Foundation
- Study coordinator: Conrad, Donald F.
Related research
Other NIH-funded projects on the same topics.
-
Week-long bioadhesive vaginal film that slowly releases antibodies to prevent pregnancy and STIs
Creating a vaginal film that slowly releases antibodies for up to seven days to help women prevent pregnancy and infections like HIV and HSV.
-
Reducing post-delivery blood pressure gaps for Black women after pregnancy
A large 2-arm study tests a postpartum blood pressure program to close racial gaps in high blood pressure after delivery, focusing on Black women with hypertensive disorders of pregnancy.
-
Molecular clues to imprinting problems after fertility treatments
This project looks for molecular clues that explain why fertility treatments can sometimes lead to imprinting problems in babies.
-
Pregnancy and newborn health at Magee-Womens Hospital
This program invites pregnant people to join research at Magee-Womens Hospital starting in early pregnancy to test ways to prevent preterm birth and improve maternal and newborn health.
-
Preeclampsia's link to small blood vessel changes in the midlife brain
This project looks at whether women who had preeclampsia during pregnancy show early small-vessel changes in the brain and related thinking differences in midlife.
-
Gene and cell therapy approaches for severe male infertility (nonobstructive azoospermia)
This project is developing gene-editing and cell-based therapies to try to restore sperm production in men with severe nonobstructive azoospermia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.