Improving genetic diagnosis and treatment for immune disorders using advanced bioinformatics.
Official title: Bioinformatics and computational biology core
Funded at Washington University · NIH-11010136 · Data updated 2026-11-12
This study is all about using advanced computer techniques to better understand genetic information for people with immune system disorders, helping doctors find the right treatments for each patient.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | April 8, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $413,985 |
| NIH project number | 1P01AI186771-01 |
| Project ID | NIH-11010136 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inborn errors of immunity who require genetic testing for targeted therapies.
✕Less likely to help
Patients with immune disorders that do not have a genetic basis or those not requiring genetic testing may not benefit from this research.
What this research studies
This research focuses on utilizing advanced bioinformatics and computational biology techniques to analyze next-generation sequencing (NGS) data, which includes various sequencing methods like whole exome and genome sequencing. By establishing a dedicated core for bioinformatics, the project aims to enhance the interpretation of complex genetic data, particularly for patients with inborn errors of immunity (IEI). The core will provide extensive annotations and computational predictions to identify pathogenic variants, ultimately aiding in the development of targeted therapies for individual patients. This approach seeks to streamline the workflow for genetic diagnosis and improve precision medicine outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more accurate genetic diagnoses and personalized treatment options for patients with immune disorders.
How similar studies have gone: Previous research has shown success in utilizing bioinformatics for genetic analysis, particularly in improving diagnosis and treatment strategies for various genetic conditions.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Itan, Yuval — Washington University
- Study coordinator: Itan, Yuval
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.