Improving gene-editing tools for zebrafish applications
ADVANCING GENE-EDITING NUCLEASES FOR DIVERSE ZEBRAFISH APPLICATIONS
This study is working on improving gene-editing tools to help scientists better understand diseases by creating more accurate models using zebrafish, which could eventually lead to new treatments for genetic disorders that might help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10912042 on NIH RePORTER |
What this research studies
This research focuses on enhancing gene-editing technologies, specifically CRISPR-Cas9, to create more precise and effective methods for modifying the genomes of zebrafish. By developing new tools like TICIT and MIC-Drop, the project aims to enable targeted integration of genetic material into specific locations in the zebrafish genome, which can help in generating accurate disease models and understanding gene functions. Patients may benefit indirectly through advancements in genetic research that could lead to new treatments for genetic disorders. The research involves collaboration between experienced labs that have made significant contributions to the field of genome editing.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with genetic disorders that could be modeled or treated using advanced gene-editing techniques.
Not a fit: Patients with conditions that are not related to genetic disorders or those who do not have access to zebrafish-based research may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for genetic disorders by improving the precision of gene editing.
How similar studies have performed: Other research has shown success with similar CRISPR-based approaches, indicating a promising avenue for future advancements in genetic therapies.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Peterson, Randall T — University of Utah
- Study coordinator: Peterson, Randall T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.