Improving gene editing techniques in zebrafish to study birth defects
Increasing the efficiency and range of prime editing for disease modeling in zebrafish
This study is working on a new way to change genes in zebrafish to help scientists better understand human birth defects and diseases, which could lead to better treatments for genetic disorders.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10774325 on NIH RePORTER |
What this research studies
This research focuses on enhancing the efficiency and range of prime editing in zebrafish, a key model organism for studying human birth defects and diseases. By utilizing a novel approach to gene editing, the researchers aim to create more precise models of genetic mutations that contribute to various congenital conditions. The methodology involves using a specialized enzyme that can make targeted changes to the zebrafish genome, allowing for better representation of human genetic variants. This could lead to improved understanding and potential treatments for genetic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital abnormalities or genetic disorders that could benefit from advanced modeling techniques.
Not a fit: Patients with conditions unrelated to genetic mutations or those not involving congenital defects may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate models for studying birth defects, ultimately improving diagnosis and treatment options for affected patients.
How similar studies have performed: Previous research has shown promise in using prime editing techniques for genetic modifications, indicating potential for success in this novel application.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Solnicakrezel, Lilianna — Washington University
- Study coordinator: Solnicakrezel, Lilianna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.