Improving gene editing in stem cells using carbon nanotubes
Official title: Enhanced CRISPR gene editing in pluripotent stem cells using carbon nanotube arrays
Funded at Advanced Gene Transfer Company, INC. · NIH-10698269 · Data updated 2026-11-12
This study is exploring a new way to make gene editing faster and safer in special stem cells that can help treat various genetic disorders, using tiny carbon tubes to deliver the necessary materials more effectively.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Advanced Gene Transfer Company, INC. NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 5, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $275,045 |
| NIH project number | 1R41GM150320-01 |
| Project ID | NIH-10698269 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders that could benefit from advanced gene editing therapies.
✕Less likely to help
Patients with conditions that do not involve genetic mutations or those who are not candidates for stem cell therapies may not benefit from this research.
What this research studies
This research aims to enhance the efficiency of CRISPR gene editing in human pluripotent stem cells, which are crucial for regenerative medicine. The team is developing a novel method using carbon nanotube arrays to facilitate the delivery of genetic materials into these cells, overcoming current challenges associated with traditional transfection methods. By utilizing these advanced devices, the research seeks to achieve faster and more effective genetic manipulation with minimal toxicity to the cells. This innovative approach could significantly improve the potential for targeted therapies in various genetic disorders.
Why it matters
Potential benefit: If successful, this research could lead to more effective gene therapies for patients with genetic disorders by improving the precision and safety of gene editing techniques.
How similar studies have gone: While CRISPR technology has shown promise in various applications, the use of carbon nanotube arrays for gene editing in stem cells is a novel approach that has not been extensively tested.
Where this research is happening
-
Advanced Gene Transfer Company, INC.
Rochester, United States Active
Researchers
- Principal investigator: Dickerson, Ian M — Advanced Gene Transfer Company, INC.
- Study coordinator: Dickerson, Ian M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.