Improving gene delivery to fat tissue using engineered viral vectors
Next generation of AAV vector targeting adipose tissue
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-11063990
This study is exploring a new way to deliver genetic material directly to fat tissue, which could lead to better treatments for obesity and related conditions, making it easier for patients to manage their health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11063990 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing the delivery of genetic material specifically to adipose (fat) tissue using advanced adeno-associated viral (AAV) vectors. The team is developing a novel dual-cassette vector design that aims to improve the efficiency and selectivity of gene transfer while minimizing unwanted effects in the liver. By engineering a hybrid capsid, they hope to overcome the limitations of traditional AAV vectors that have struggled to effectively target adipose tissue. Patients may benefit from this approach if it leads to better treatments for conditions related to fat metabolism and obesity.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with obesity or metabolic disorders that could benefit from targeted gene therapy.
Not a fit: Patients who do not have conditions related to adipose tissue or metabolic disorders may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective gene therapies for obesity and related metabolic disorders.
How similar studies have performed: Previous research has shown promising results with AAV vectors in other tissues, but this specific approach targeting adipose tissue is relatively novel.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CAO, LEI — OHIO STATE UNIVERSITY
- Study coordinator: CAO, LEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.