Improving gene delivery to fat tissue using engineered viral vectors
Official title: Next generation of AAV vector targeting adipose tissue
Funded at Ohio State University · NIH-11063990 · Data updated 2026-11-12
This study is exploring a new way to deliver genetic material directly to fat tissue, which could lead to better treatments for obesity and related conditions, making it easier for patients to manage their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $487,463 |
| NIH project number | 5R01DK137431-02 |
| Project ID | NIH-11063990 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with obesity or metabolic disorders that could benefit from targeted gene therapy.
✕Less likely to help
Patients who do not have conditions related to adipose tissue or metabolic disorders may not receive any benefit from this research.
What this research studies
This research focuses on enhancing the delivery of genetic material specifically to adipose (fat) tissue using advanced adeno-associated viral (AAV) vectors. The team is developing a novel dual-cassette vector design that aims to improve the efficiency and selectivity of gene transfer while minimizing unwanted effects in the liver. By engineering a hybrid capsid, they hope to overcome the limitations of traditional AAV vectors that have struggled to effectively target adipose tissue. Patients may benefit from this approach if it leads to better treatments for conditions related to fat metabolism and obesity.
Why it matters
Potential benefit: If successful, this research could lead to more effective gene therapies for obesity and related metabolic disorders.
How similar studies have gone: Previous research has shown promising results with AAV vectors in other tissues, but this specific approach targeting adipose tissue is relatively novel.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Cao, Lei — Ohio State University
- Study coordinator: Cao, Lei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.