Improving frailty in older cancer survivors by targeting aging cells
Official title: Targeting Senescence to Improve Frailty in Older Cancer Survivors
Funded at University of California Los Angeles · NIH-10920486 · Data updated 2026-11-12
This study is looking at how cancer treatment can make older adults over 65 age faster and become frail, which can lead to losing independence and being at higher risk for falls and other health issues, and it’s testing a special type of medicine that might help improve their health by getting rid of old, tired cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $242,995 |
| NIH project number | 5K76AG074918-03 |
| Project ID | NIH-10920486 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above who have survived cancer and are experiencing frailty.
✕Less likely to help
Patients who are younger than 65 or those who have not undergone cancer treatment may not benefit from this research.
What this research studies
This research investigates how cancer treatment accelerates aging in individuals over 65, leading to frailty, which can result in loss of independence and increased risk of falls and death. The study focuses on understanding the role of cellular senescence, a state where cells stop dividing, in contributing to frailty among older cancer survivors. By exploring the effects of senolytic drugs, such as fisetin, which can eliminate these senescent cells, the research aims to develop interventions that may improve health outcomes for this vulnerable population.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce frailty and improve the quality of life for older cancer survivors.
How similar studies have gone: Previous studies have shown promising results in targeting senescence to improve health outcomes, indicating that this approach may be effective.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Sedrak, Mina S — University of California Los Angeles
- Study coordinator: Sedrak, Mina S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.